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Ketamine Therapy Clinics in California

Browse 341 medical ketamine centers and 285 ketamine-assisted psychotherapy providers in California. Find IV infusion, Spravato, telehealth, and KAP providers for depression, anxiety, PTSD, and more.

Browse 626 providersFind your city
Providers
626
Cities
182
Medical centers
341
KAP therapists
285

Ketamine Therapy in California

California hosts the largest ketamine therapy network of any U.S. state, with 626 listed providers across 182 cities. The diversity of both geography and treatment approach makes California a useful model for understanding the full range of what ketamine therapy can look like.

Browse by City (182)

Each city page lists every local provider with treatment details.

Browse by Metro Area:

San Francisco Bay AreaLos Angeles

Cities with the most providers

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All Providers in California (626)

Medical Centers (341) Clinics offering IV infusion, IM injection, Spravato (esketamine nasal spray), and other medical ketamine treatments.

Ketamine-Assisted Psychotherapy (285) Licensed therapists offering ketamine-assisted psychotherapy (KAP) for depression, anxiety, PTSD, and trauma. Often paired with at-home protocols.

Showing 24 of 626 providers in California

Treatment Types Available

California's providers collectively offer nearly every ketamine delivery format. Spravato (esketamine) nasal spray is the most common, available at 315 locations. Spravato is FDA-approved for treatment-resistant depression and, in a separate indication, for major depressive disorder with suicidal ideation; it is administered in certified clinical settings and frequently covered by insurance for qualifying patients.

Ketamine-Assisted Psychotherapy (KAP) is the second-largest modality, offered at 285 providers — an unusually high proportion that reflects California's large licensed mental health workforce. KAP pairs a ketamine experience with therapeutic support from a licensed clinician, addressing conditions such as depression, anxiety, PTSD, and trauma. IV infusion is available at 179 clinics statewide. A smaller number of providers also list IM injection (4), telehealth (5), nasal/Spravato variants (4), at-home (1), compounding pharmacy (1), and oral/sublingual (1) options.

Where Providers Are Located

Southern California and the Bay Area dominate in raw numbers, but coverage extends well inland. San Diego leads all cities with 45 providers, followed by Los Angeles (40) and San Francisco (28). The Sacramento metro — including Sacramento (22) and Roseville (13) — forms a significant northern hub. The East Bay is well-covered through Oakland (18) and Berkeley (15). In Orange County, Irvine (16) and Newport Beach (11) serve the southern end of the Los Angeles metro. Long Beach (14), Pasadena (12), and San Jose (12) round out the top tier.

Medical Clinics and KAP Practices

Of California's 626 providers, 341 operate as medical clinics and 285 specialize in ketamine-assisted psychotherapy. The overlap between these categories is significant — some practices combine medical administration with integrated therapeutic support. Conditions commonly addressed include treatment-resistant depression, anxiety disorders, PTSD, chronic pain, and related conditions, though individual suitability depends on a clinical assessment.

Cost & Insurance

Spravato administered under physician supervision has a defined insurance coverage pathway for qualifying diagnoses. IV infusion, IM injection, and other off-label formats are typically out-of-pocket costs, and fee structures vary considerably between providers and regions of the state. KAP sessions may or may not be covered depending on how the practice bills — ask each provider directly.

Starting Your Search

Use the directory listings to narrow by city and treatment type, then contact providers directly to confirm pricing, insurance acceptance, current availability, and intake processes. Details change; always verify with the clinic before scheduling.