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Ketamine Therapy Clinics in North Carolina

Browse 111 medical ketamine centers and 53 ketamine-assisted psychotherapy providers in North Carolina. Find IV infusion, Spravato, telehealth, and KAP providers for depression, anxiety, PTSD, and more.

Browse 164 providersFind your city
Providers
164
Cities
51
Medical centers
111
KAP therapists
53

Ketamine Therapy in North Carolina

North Carolina's ketamine therapy network is one of the more developed in the Southeast, with 164 listed providers distributed across 51 cities. The state supports three major treatment modalities and has strong provider density in both its largest metros and several mid-size communities.

Browse by City (51)

Each city page lists every local provider with treatment details.

Cities with the most providers

All 51 cities in North Carolina, A–Z

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All Providers in North Carolina (164)

Medical Centers (111) Clinics offering IV infusion, IM injection, Spravato (esketamine nasal spray), and other medical ketamine treatments.

Ketamine-Assisted Psychotherapy (53) Licensed therapists offering ketamine-assisted psychotherapy (KAP) for depression, anxiety, PTSD, and trauma. Often paired with at-home protocols.

Showing 24 of 164 providers in North Carolina

Cities with Ketamine Providers

North Carolina's geographic breadth is a notable strength. Asheville and Charlotte are tied at 16 providers each — a reflection of both the state's urban centers and Asheville's historically progressive wellness culture. Raleigh (13), the state capital, is followed by Wilmington (11) on the coast and Greensboro (10) in the Piedmont. The Research Triangle is well-covered: Chapel Hill (9), Cary (8), and Durham (8) together offer significant access. Western NC adds Hickory (7), while the Triad region gains further support from Winston-Salem (5). Mooresville (4) and Apex (4) round out the top cities. In total, 51 distinct cities across the state have at least one listed provider.

Modalities Offered

Spravato (esketamine) is the most widely available treatment, listed at 108 locations. The FDA-approved nasal spray is administered in a certified clinical setting and is often eligible for insurance coverage for qualifying patients with treatment-resistant depression. Ketamine-Assisted Psychotherapy (KAP) is offered at 53 practices, integrating licensed therapeutic support — preparation, the ketamine session, and integration work — for a more comprehensive mental health approach. IV ketamine infusion is available at 31 clinics, representing a significant medical treatment option for those whose providers recommend the intravenous route. One provider offers telehealth services.

Medical vs. KAP Providers

North Carolina's 164 total providers split into 111 medical clinics and 53 KAP practices. This balance means patients can find both medically supervised infusion or Spravato care and therapy-integrated approaches within the same state, often within the same community. Some individuals work with both a medical provider and a separate KAP therapist.

Conditions and Eligibility

Ketamine therapy in North Carolina is most often explored for treatment-resistant depression, anxiety disorders, PTSD, and certain chronic pain syndromes. Individual eligibility is assessed on a case-by-case basis by each provider and typically involves a clinical intake evaluation.

Cost & Insurance

Spravato has the clearest insurance coverage pathway. Off-label IV infusion is generally out-of-pocket, as is most KAP. Costs vary considerably by provider, city, and treatment plan. Before beginning care, request a clear fee schedule and ask explicitly about insurance billing.

Finding a Provider

Use this directory to narrow your search by city and modality, then contact clinics directly to confirm availability and ask intake questions. Provider information can change, so direct contact with each practice is always recommended.